Search results for "modelos de riesgos proporcionales"

showing 9 items of 9 documents

Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.

2017

Background-The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. Methods and Results-We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4.8 years. We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations …

0301 basic medicineMaleTime FactorsMediterranean dietEpidemiologymodelos de riesgos proporcionaleshumanosSistema cardiovascular -- Malaltieséteres de fosfolípidosDisease030204 cardiovascular system & hematologyGut floraDiet MediterraneanCholinechemistry.chemical_compound0302 clinical medicineBetainecardiovascular diseaseRisk FactorsTandem Mass Spectrometryestudios prospectivosmetabolómicaCholineProspective StudiesTrimethylamine-n-oxidemediana edadOriginal ResearchDiet and Nutritionmetilaminas2. Zero hungerAged 80 and overChromatographyancianoCholine metabolismbiologydietaresultado del tratamientoIncidencePhospholipid Ethersdistribución de la ji al cuadradoMiddle AgedCardiovascular disease3. Good healthPrimary PreventioncolinaTreatment OutcomeCardiovascular Diseasesespectrometría de masas en tándemPlasma concentrationProfileFemaleCardiology and Cardiovascular Medicinefosforilcolinamedicine.medical_specialtyPhosphorylcholineestudios de casos y controlesenfermedades cardiovascularesGut microbiotaincidencia03 medical and health sciencesMethylaminesfactores de tiempoInternal medicineMediterranean dietOxidationmedicinefactores de riesgoHumansMetabolomicsanálisis multifactorialDieta -- Mediterrània Regió de lacromatografíaAgedProportional Hazards ModelsChi-Square Distributiongut microbiotabusiness.industrybetaínaPlasma sanguiniLifestylebiology.organism_classificationPredimedDietBetainePhosphatidylcholine030104 developmental biologyEndocrinologychemistrySpainCase-Control StudiesMultivariate AnalysisbusinessBiomarkersChromatography Liquid
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A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk

2014

© 2014 Castro-Quezada et al. Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food freque…

GerontologyMalePhysiologyEpidemiologymodelos de riesgos proporcionaleshumanoslcsh:MedicineDieta mediterràniaFatsElderlyRisk Factorsíndice glucémicoCause of DeathMedicine and Health SciencesMedicinelcsh:Sciencemediana edadAged 80 and overeducation.field_of_studyancianoMultidisciplinaryDeath ratesGeographyGeographical regionsdietaMortality rateHazard ratioRegional geographyAge FactorsMiddle AgedGlycemic indexCardiovascular diseasesQuartilePhysiological ParametersCardiovascular DiseasesFemaleDietaResearch Articlemedicine.medical_specialtyPopulationCarbohydratesenfermedades cardiovascularesBlood sugarNational Death Indexcausas de muerteInternal medicineGlycemic loadDietary CarbohydratesMortalitatHumansfactores de riesgoObesityFatty acidsMortalityeducationCardiovascular Disease EpidemiologyGlycemicNutritionAgedProportional Hazards Modelsconducta alimentariabusiness.industryPhysical activitycarbohidratos dietéticosMalalties cardiovascularslcsh:RBody WeightBiology and Life SciencesPREDIMED studyNutrientsFeeding BehaviorGenitourinary cancersDietEarth sciencesGlucèmiaGeriatricsGlycemic IndexGlycemiclcsh:QMediterranean Basinbusinesshuman activities
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CLOCK gene variation is associated with incidence of type‑2 diabetes and cardiovascular diseases in type‑2 diabetic subjects: dietary modulation in t…

2016

Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However, no longitudinal study has investigated the association between CLOCK…

Male0301 basic medicineTime Factorsmodelos de riesgos proporcionalesEndocrinology Diabetes and MetabolismhumanosCLOCK ProteinsType 2 diabetesKaplan-Meier Estimatefrecuencia génica030204 cardiovascular system & hematologyDiet Mediterranean0302 clinical medicineGene FrequencyRisk Factorsevaluación de riesgosLongitudinal Studiesmediana edadOriginal InvestigationAged 80 and overancianoDiabetishomocigotodietaIncidenceresultado del tratamientoHomozygoteDiabetesdistribución de la ji al cuadradoMiddle AgedCircadian RhythmCLOCKStrokePhenotypeTreatment OutcomeCardiovascular diseasesinteracción gen-ambientediabetes mellitusfenotipoCardiology and Cardiovascular Medicineestimación de Kaplan-Meiermedicine.medical_specialtyHeterozygoteenfermedades cardiovascularesSingle-nucleotide polymorphism:Ciencias de la Salud::Nutrición y dietética [Materias Investigacion]Polymorphism Single NucleotideRisk Assessmentincidencia03 medical and health sciencesInsulin resistanceMediterranean cookingfactores de tiempo:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Diabetes mellitusInternal medicineSistema cardiovascular -- Malalties -- Aspectes genèticsMediterranean dietCuina mediterràniamedicineSNPHumansproteínas CLOCKfactores de riesgoGenetic Predisposition to DiseaseCircadian rhythmanálisis multifactorialDieta -- Mediterrània Regió de laAgedProportional Hazards ModelsChi-Square DistributionCLOCK genebusiness.industryMalalties cardiovascularspredisposición genética a la enfermedadProtective Factorsmedicine.diseaseObesityDiet030104 developmental biologyEndocrinologyritmo circadianoDiabetes Mellitus Type 2SpainMultivariate Analysisestudios longitudinalesGene-Environment Interactionbusiness:Ciencias de la Salud::Endocrinología [Materias Investigacion]heterocigoto
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Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

2016

Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; BACKGROUND Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result in a significant reduction in chronic GVHD 2 years after allogeneic peripheral-blood stem-cell transplantation from an HLA-identical sibling. METHODS We conducted a prospective, multicenter, open-label, randomized phase 3 study of ATG as part of …

Male:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Proportional Hazards Models [Medical Subject Headings]T-LymphocytesPhases of clinical researchGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Linfocitos t:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Immunosuppressive Agent0302 clinical medicineTrasplante homólogoEstudios prospectivosMedicineCumulative incidenceProspective StudiesProspective cohort studyChildTransplantation Homologou:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immune Sera::Antilymphocyte Serum [Medical Subject Headings]Acute leukemia:Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes::T-Lymphocytes [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]Medicine (all)IncidenceSuero antilinfocíticoGeneral MedicineMiddle AgedModelos de riesgos proporcionales3. Good healthHumanosSurvival Rate030220 oncology & carcinogenesis:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Child PreschoolFemale:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings]Immunosuppressive AgentsHumanHomologousAdultmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]AdolescentEnfermedad injerto contra huéspedDisease-Free Survival03 medical and health sciencesYoung AdultInternal medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansTransplantation HomologousSupervivencia sin enfermedadPreschoolSurvival rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Antilymphocyte SerumProportional Hazards ModelsTransplantationbusiness.industryEnfermedad crónicamedicine.diseaseInmunosupresoresAnti-thymocyte globulinSurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Prospective Studie:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]Graft-versus-host diseaseT-Lymphocyte:Check Tags::Female [Medical Subject Headings]Chronic DiseaseProportional Hazards ModelAdolescent; Adult; Antilymphocyte Serum; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Survival Rate; T-Lymphocytes; Transplantation Homologous; Young Adult; Medicine (all)business030215 immunology
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Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta ME…

2016

12 Páginas.-- 6 Tablas.-- 1 Figura

MaleGerontologyTime FactorsEpidemiologymodelos de riesgos proporcionaleshumanos030204 cardiovascular system & hematologychemistry.chemical_compound0302 clinical medicineRisk Factorsestudios prospectivosevaluación de riesgosMedicineNutsSudden cardian death030212 general & internal medicineFood scienceLongitudinal StudiesProspective Studiesmediana edadOriginal ResearchDiet and NutritionAged 80 and overchemistry.chemical_classificationeducation.field_of_studyancianoalpha-Linolenic aciddietaFactors de risc en les malaltiesHàbits alimentarisFatty Acidsω-3 fatty acidsFatty acids in human nutritionalpha-Linolenic Aciddistribución de la ji al cuadradoMiddle AgedCardiovascular systemnutritionCardiovascular DiseasesFemaleDietaCardiology and Cardiovascular MedicineNutritive Valueconducta de reducción del riesgoRisk factors in diseasesFood habitsPopulationenfermedades cardiovasculares030209 endocrinology & metabolismJuglansRisk Assessmentsudden cardiac death03 medical and health sciencesalimentos del marfactores de tiempoMediterranean cookingÀcids grassos en la nutricióFatty Acids Omega-3Cuina mediterràniaPeix com a alimentHumansfactores de riesgoanálisis multifactorialeducationOlive OilDieta -- Mediterrània Regió de laDieta mediterraneaácidos grasosα-linolenic acidAgedProportional Hazards ModelsSistema cardiovascularChi-Square Distributionbusiness.industryCorrectionFatty acidHàbits alimentaris -- Mediterrània Regió de laProtective FactorsFish consumptionPredimedDietnueceschemistrySeafoodSpainMultivariate Analysisvalor nutritivoestudios longitudinalesfatty acidbusinessRisk Reduction Behaviorácido alfa-linolénico
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Obesity indexes and total mortality among elderly subjects at high cardiovascular risk: The PREDIMED study

2014

Background: Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them …

MaleGerontologymodelos de riesgos proporcionaleshumanosDieta mediterràniaBody Mass IndexWaist–hip ratioRisk FactorsMedicine and Health SciencesAbdominal obesitymediana edadAged 80 and overClinical Trials as TopicancianoMultidisciplinaryAnthropometryMortality rateHazard ratioQAge FactorsRMiddle AgedCardiovascular diseasesResearch DesignCardiovascular DiseasesPhysical SciencesObservational StudiesMedicineObesitatFemalemedicine.symptomWaist CircumferenceStatistics (Mathematics)Research ArticlePREDIMEDWaistClinical Research DesignScienceCardiologyenfermedades cardiovascularesResearch and Analysis Methodsensayos clínicos como asuntomedicineHumansfactores de riesgoObesityStatistical MethodsMortalityobesidadAgedProportional Hazards Modelsperímetro abdominalbusiness.industryWaist-Hip RatioMalalties cardiovascularsíndice de masa corporalAnthropometrymedicine.diseaseCardiovascular riskObesityíndice cintura-caderabusinessBody mass indexMathematicsMeta-AnalysisDemographyAntropometria
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Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study

2015

Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk we…

MaleMediterranean dietmodelos de riesgos proporcionaleshumanosSistema cardiovascular -- Malaltiesestudios de seguimientoDiet MediterraneanDietary inflammatory indexBody Mass Indexcardiovascular diseaseRisk Factorsestudios prospectivosSurveys and QuestionnairesNutsProspective StudiesProspective cohort studymediana edadAged 80 and overancianoNutrition and Dieteticsdietaresultado del tratamientoIncidenceIncidence (epidemiology)Hazard ratioMiddle AgedCardiovascular diseaseInflamaciódeterminación del punto finalCardiovascular diseasesTreatment OutcomeQuartileCardiovascular Diseasesdietary inflammatory indexFemalelcsh:Nutrition. Foods and food supplyPREDIMEDmedicine.medical_specialtyEndpoint DeterminationPromoció de la salutenfermedades cardiovasculareslcsh:TX341-641Context (language use):Ciencias de la Salud::Nutrición y dietética [Materias Investigacion]incidenciaArticleMediterranean cookinginflamaciónInternal medicineCuina mediterràniaingesta energéticamedicinefactores de riesgoHumansanálisis multifactorialOlive OilAgedProportional Hazards ModelsInflammationMalalties cardiovascularsbusiness.industryProportional hazards modelíndice de masa corporalDietSurgerynuecesMultivariate AnalysisHealth promotionEnergy IntakebusinessBody mass indexFollow-Up StudiesFood ScienceNutrients
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Impact of psychosocial factors on cardiovascular morbimortality: a prospective cohort study

2014

[Background] Whilst it is well known that psychosocial determinants may contribute to cardiovascular diseases (CVD), data from specific groups are scarce. The present study aims to determine the contribution of psychosocial determinants in increasing the risk of cardiovascular events (myocardial infarction and stroke), and death from CVD, in a high risk adult population.

MaleTime Factorsmodelos de riesgos proporcionalesEpidemiologyhumanosdepresiónMyocardial Infarction1471-2261Social supportdisparidades en el estado de saludClinical trialsRisk Factorsestudios prospectivosCause of Deathevaluación de riesgosMedicineLongitudinal StudiesProspective StudiesProspective cohort studyStrokemediana edadHealth inequalitiesCause of deathAged 80 and overeducation.field_of_studyancianoDepressionFactors de risc en les malaltiesHazard ratioMiddle AgedPrognosisStrokepronósticoSocioeconomic positionCardiovascular diseasesEstudi de casosEducational StatusFemaleRisk assessmentCardiology and Cardiovascular MedicinePsychosocialResearch Articlemedicine.medical_specialtyRisk factors in diseasesPopulationAcute myocardial infarctionRisk AssessmentEducational levelfactores de tiempocausas de muerteInternal medicinefactores de riesgoHumansanálisis multifactorialaccidente cerebrovascularcardiovascular diseaseseducationEpidemiologiainfarto de miocardioAgedProportional Hazards Modelsbusiness.industryProportional hazards modelMalalties cardiovascularsHealth Status Disparitiesmedicine.diseaseapoyo socialMorbiditatSpainMultivariate AnalysisPhysical therapyHousingCardiovascular deathestudios longitudinalesCase studiesMorbiditybusinessAssaigs clínics
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Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

2014

[Background] Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk.

MaleriesgoMediterranean dietmodelos de riesgos proporcionaleshumanosPhysiologyDiet MediterraneanAntioxidantsRisk FactorsSistema cardiovascular--MalaltiesCause of DeathNeoplasmsflavonoidesEpidemiologyStilbenesHydroxybenzoates1741-7015mediana edadCause of deathAged 80 and overMedicine(all)neoplasiasancianodietaHazard ratiofood and beveragesGeneral MedicineMiddle AgedCardiovascular diseaseAll-cause mortalityMetabolismeCardiovascular DiseasesPolifenolsFemaleResearch ArticleRiskPREDIMEDmedicine.medical_specialtyenfermedades cardiovascularesLignansInsulin resistanceMediterranean cookingMedical statisticscausas de muertehidroxibenzoatosMediterranean dietCuina mediterràniaantioxidantesmedicineMortalitatHumansfactores de riesgoFood consumptionMortalitypolifenolesAgedProportional Hazards ModelsFlavonoidsProportional hazards modelbusiness.industryPolyphenolsPREDIMED studyPolyphenol intakemedicine.diseaseConfidence intervalBiotechnologyDietMetabolismPolyphenolCommentarybusinessEstadística mèdicaConsum d'aliments
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